Nature Medicine
288,375 followers
Jiwa Pejuang 
Abdul Noormohamed 
human_not_bees 
Results from phase 2 SIGNAL study of #pepinemab #immunotherapy in early #HuntingtonsDisease suggest a treatment-related reduction in caudate #brain atrophy and reversal of brain metabolic activity decline that is typical of #HD progression. #NMEDClinical
nature.com/articles/s4159…
Financing the health needs of Ukrainian refugees.
Correspondence from Wu Zeng @Georgetown.
nature.com/articles/s4159…
Choosing Wisely for oncology in Brazil: 10 recommendations to deliver evidence-based cancer care.
Correspondence from Fabio Ynoe de Moraes and colleagues @LACOG_group
nature.com/articles/s4159…
The use of animal organs in humans - xenotransplanation - is more than 100 years old, but is now accelerating due to genetically modified pig organs that are not rejected.
Robert Montgomery at @nyulangone lays out next steps for the field @NatureMedicine
nature.com/articles/s4159…
Retweeted by Nature Medicine Make deep learning #AI algorithms in computational pathology more reproducible and reusable.
Comment from @p_tingying @MarrCarsten and colleagues @helmholtz_ai
nature.com/articles/s4159…
📢 Less than 2 weeks till the abstract deadline! Submit by August 22nd to our digital health conference 'Medicine in a Virtual Age'. It's a fully virtual event and completely free to attend. �cvent.com/c/abstracts/85…d#MedInVirtualAge222#digitalhealtht#AIAI
Findings from the #TUXEDO-1 trial demonstrate efficacy of the #antibody-drug conjugate trastuzumab deruxtecan for treatment of brain metastases in patients with #HER2-positive #BreastCancer. #CNS #Cancer #NMEDClinical @MedUni_Wien
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News & Views: Survivors of childhood #cancer have high rates of morbidity in later life. LInda Vrooman and Lisa Diller @DanaFarber @BostonChildrens discuss models to predict severe obesity, which could promote early interventions & better long-term care.
nature.com/articles/s4159…
Next steps for the xenotransplantation of pig organs into humans.
Comment from Robert Montgomery and colleagues @nyulangone.
nature.com/articles/s4159…
A report from large cohorts of adult survivors of childhood #cancer demonstrates that polygenic scores improve the risk prediction of developing severe #obesity, providing opportunities for surveillance and mitigation interventions @YadavSapkota8 @StJude nature.com/articles/s4159…
A blueprint for eliminating cholera by 2030.
Comment from Md Taufiqul Islam and colleagues @icddr_b
nature.com/articles/s4159…
Results from a pivotal single-arm phase 2 trial shows that the repeated intratumoral administration of the #oncolytic herpes virus G47∆ in residual or recurrent #glioblastoma exhibits survival benefit and a safe profile #NMEDClinical nature.com/articles/s4159…
This week is #WorldBreastfeedingWeek! Exclusive #breastfeeding (EBF) is one of the most effective strategies for preventing #ChildMortality. We look back at a fine-scale geospatial analysis of the prevalence of EBF across #Africa from 2000–2017.
nature.com/articles/s4159…
"Is my baby latching properly?"
"Has my milk dried up?"
"Is it safe to take my medication?"
#Breastfeeding counselling can provide reassurance, build confidence and help solve problems.
#WorldBreastfeedingWeek
Retweeted by Nature Medicine “As we learn more, what we do know is clear: the danger of polio is present in New York today,” Mary Bassett, the state health commissioner, said in a press release. buff.ly/3JAWjMQ
Retweeted by Nature Medicine An engineered protein engages the efferocytosis pathway to induce beta-#amyloid engulfment, resulting in behavioral rescue in #Alzheimers models without the increased inflammation or vascular pathology seen with conventional antibody therapy. @wonsukchung
nature.com/articles/s4159…
With so many people having been infected with SARS-CoV-2, clinicians are wondering whether the pandemic will be followed by a cardiovascular aftershock. @Nature reports how researchers are trying to understand the heart-related risks. go.nature.com/3By7y6A
Retweeted by Nature Medicine Preliminary results from a phase 1/2 trial with 18 months follow up show that transplantation of #CRISPR/Cas9 BCL11A-edited autologous #hematopoietic cells in two pediatric patients with #BetaThalassemia was safe and achieved transfusion independence.
nature.com/articles/s4159…
A retrospective analysis of primary care records in the UK reveals individual symptoms associated with #SARS-CoV-2 infections that persisted for 12 weeks or more post-infection, as well as risk factors associated with developing #LongCOVID @unibirmingham nature.com/articles/s4159…
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access.
Comment from Veerle Visser-Vandewalle, Michael Okun and colleagues @UniCologne @UF
nature.com/articles/s4159…
Fostering drug discovery and development in Africa.
Comment from @Kelly_Chibale and colleagues @H3D_UCT @UCT_news
nature.com/articles/s4159…
Financing the health needs of Ukrainian refugees.
Correspondence from Wu Zeng @Georgetown.
nature.com/articles/s4159…
A blueprint for eliminating cholera by 2030.
Comment from Md Taufiqul Islam and colleagues @icddr_b
nature.com/articles/s4159…
To overcome limitations of previous GWAS studies of #CoronaryArteryDisease, this study incorporates a cohort of individuals containing large fractions of Black and Hispanic individuals, providing a wider perspective of the genetic landscape of this disease
nature.com/articles/s4159…
In a phase 2 trial, monitoring tumor resistance mutations in blood using liquid #biopsies allowed to rationally guide subsequent therapy with anti-EGFR antibodies in patients with #ColorectalCancer. #EGFR #biomarkers #Cancer @Albert0Bardelli @BardelliLab
nature.com/articles/s4159…
The US Supreme Court’s overturning of Roe v Wade threatens the health and freedom of all Americans. Industries that support personal privacy & freedoms, diversity & equity, must now use their voice and financial power to defend reproductive rights ⚖️
nature.com/articles/s4159…
The #HIV prevention and treatment landscape is changing with the arrival of long-acting agents; in our recent News and Views, Linda-Gail Bekker takes stock of recent advances and what this means for patients.
@LindaGailBekker @DTHF_SA
nature.com/articles/s4159…
Serial injections of oncolytic virus therapy shows promise in patients with #glioblastoma, opening the door to longitudinal study designs that could yield rich insights.
News and Views from John D. Christie & E. Antonio Chiocca @BrighamWomens @harvardmed
nature.com/articles/s4159…
⭐New Research Highlight: Violence against women is a public health problem and is widely under-reported; a large study in India showed that gender-based police interventions led to increased reporting of gender-based violence.
@ScienceMagazine
nature.com/articles/d4159…
The prospective evaluation of a #MachineLearning based early warning system for #sepsis showed that interaction of health care providers with the system was associated with better patient outcomes, including reduced in-hospital mortality @suchisaria nature.com/articles/s4159…
The prospective evaluation of a #MachineLearning based early warning system for #sepsis showed that health care providers interacted with the system at a high rate, and that this interaction was associated with faster #antibiotic ordering @suchisaria nature.com/articles/s4159…
A new modeling study demonstrates that most countries could achieve 80-80-80 #hypertension targets by 2040, promoting increased global #equality for #cardiovascular diseases, with the greatest benefits in low-income countries @davidawatkins @ResolveTSL
nature.com/articles/s4159…
⭐Research Highlight: A once-daily combination hormone treatment led to reductions in #endometriosis associated pain and opioid use for the duration of a 6-month study
@TheLancet
nature.com/articles/d4159…
In our recent News and Views, T. Jake Liang from @NIDDKgov discusses new strategies based on nucleic acid technologies to treat chronic #hepatitis B
#WorldHepatitisDay
nature.com/articles/s4159…
A first-in-human study of an #antisense oligonucleotide targeting #hepatitis B virus RNA provides initial insights into this potential new therapeutic modality for individuals with chronic #HBV infection #ASO @HKUniversity #NMEDClinical
#WorldHepatitisDay
nature.com/articles/s4159…
Today is #WorldHepatitisDay
Take a look at our comment from researchers @KirbyInstitute discussing how to achieve @WHO 's targets for eliminating #hepatitis C virus by 2030 #globalhealth
nature.com/articles/s4159…
📢We are accepting abstracts! Don't forget to submit by August 22nd for our digital health conference#MedInVirtualAge222, which will be a fully virtual event and completely free to attend.twitter.com/NatureConf/sta…I
Financing the health needs of Ukrainian refugees.
Correspondence from Wu Zeng @Georgetown.
nature.com/articles/s4159…
Deep brain stimulation for obsessive–compulsive disorder: a crisis of access.
Comment from Veerle Visser-Vandewalle, Michael Okun and colleagues @UniCologne @UF
nature.com/articles/s4159…
A retrospective analysis of primary care records in the UK reveals individual symptoms associated with #SARS-CoV-2 infections that persisted for 12 weeks or more post-infection, as well as risk factors associated with developing #LongCOVID @unibirmingham nature.com/articles/s4159…
A report from large cohorts of adult survivors of childhood #cancer demonstrates that polygenic scores improve the risk prediction of developing severe #obesity, providing opportunities for surveillance and mitigation interventions @YadavSapkota8 @StJude nature.com/articles/s4159…
Fostering drug discovery and development in Africa.
Comment from @Kelly_Chibale and colleagues @H3D_UCT @UCT_news
nature.com/articles/s4159…
A blueprint for eliminating cholera by 2030.
Comment from Md Taufiqul Islam and colleagues @icddr_b
nature.com/articles/s4159…
A prospective national cohort evaluating ring MVA vaccination as post-exposure prophylaxis for monkeypox.
Correspondence from @LiemBinhLuongN1 @odile_launay and colleagues @CIC1417, France
nature.com/articles/d4159…
News and Views: The #HIV prevention and treatment landscape is changing with the arrival of long-acting agents; Linda-Gail Bekker takes stock of recent advances and what this means for patients.
@LindaGailBekker @DTHF_SA
nature.com/articles/s4159…
Epidemics and pandemics can be prevented if funding is increased for emerging infections, especially in low and middle income countries. This will boost infrastructure in hotspots and ensure that research reflects local priorities, rather than neo-colonialist attitudes (6 of 6)
Laboratory diagnosis and sequencing capacity built for SARS-CoV-2 is being dismantled.
This should be maintained and used for other diseases, including emerging viruses like monkeypox, to improve health and boost the economy: a healthy worker is a productive worker (5 of 6)
Every zoonotic infection should be a cause for concern, but research funding seems to flow only when high-income countries are heavily affected.
More research is needed on dengue, Ebola, Marburg, Crimean-Congo hemorrhagic fever, Lassa fever, Nipah and others.
(4 of 6)
Many questions about monkeypox could have been answered during decades of outbreaks in Western and Central Africa.
What is the animal reservoir? How effective are smallpox vaccines? Which anti-virals work? How does the virus transmit from person-to-person?
(3 of 6)
In 2017 an outbreak of monkeypox spread in Nigeria after a 40-year absence. Orthopoxvirus research dropped off the cliff after the eradication of smallpox, but this funding should have re-started in 2017, or before.
(2 of 6)
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