Nature Medicine
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Microglial activation and tau accumulation propagate together in patients with Alzheimer's disease suggesting a synergistic interaction that determines disease progression #Alzheimers @TharickAPascoal @PittPsychiatry @pedrorosaneto @IPNMcGill nature.com/articles/s4159…
Lessons on COVID-19 from Indigenous and remote communities of the Arctic.
Correspondence from Andrey N. Petrov and colleagues @ARCTICenterUNI
nature.com/articles/s4159…
⭐ Research Highlight: Early but encouraging results with a bispecific antibody for treatment of multiple myeloma, according to a phase 1 clinical trial published in @TheLancet
nature.com/articles/d4159…
In a first-in-human #phase1trial, autologous tumor infiltrating lymphocyte therapy in patients with metastatic #lungcancer is safe and shows clinical efficacy in association with neoantigen-specific T cell activity @BenCreelan @MoffittNews #NMEDClinical nature.com/articles/s4159…
In a double-blind, randomized phase 2 #clinicaltrial, treatment of patients with #heartfailure with preserved ejection fraction (HFpEF) with the oral anti-fibrotic agent pirfenidone reduced myocardial fibrosis. #NMEDClinical @NWhearts @OfficialUoM nature.com/articles/s4159…
Our #genetics editor @AnnaRanzoni is attending the virtual #HCA2021DevPed meeting this week. Get in touch if you'd like to chat and learn more about @NatureMedicine!
A new #machinelearning approach integrating 2.1 billion measurements of 92 different lab tests from 2.8 million adults produces models that can stratify one's risk of having future abnormal lab test levels and subsequent emerging disease @WeizmannScience nature.com/articles/s4159…
Whole genome #sequencing of metastatic #biopsies longitudinally sampled during the course of anti-cancer treatment reveals the actionable #cancer genome remains relatively stable over time. @NKI_nl @oncodeinstitute @jorisvandehaar #genomics nature.com/articles/s4159…
The association between certain #mitochondrialDNA variants and increased risk of late-onset diseases in humans could be explained by a direct role of mitochondrial DNA in the regulation of cellular proteostasis @caina89 @nicolesoranzo @OliverStegle
nature.com/articles/s4159…
Few topics in medicine are as controversial right now as the approval of aducanumab for Alzheimer's disease.
To try to cover this evenly, we at @NatureMedicine published two alternative opinions on what this decision by @US_FDA means for Alzheimer's research.
Firstly.... (1/3)
Retweeted by Nature Medicine ⚡Read our new editorial⚡
"Gene therapies should be for all" #genetherapy #equity nature.com/articles/s4159…
⭐ Research Highlight: A study published in @CellCellPress shows how fermented foods such as keffir and kimchi enhance microbiome diversity and reduce markers of inflammation.
nature.com/articles/d4159…
Lessons on COVID-19 from Indigenous and remote communities of the Arctic.
Correspondence from Andrey N. Petrov and colleagues @ARCTICenterUNI
nature.com/articles/s4159…
The @US_FDA approval of aducanumab for Alzheimer's disease was controversial.
Joel Perlmutter and Jeffrey Cummings present alternative opinions on what this approval means for Alzheimer's research.
Perlmutter: nature.com/articles/s4159…
Cummings: nature.com/articles/s4159…
A new cluster randomized trial in 13 American states shows that a #socialmedia campaign with videos of healthcare professionals to encourage users to stay at home over the holidays was effective in reducing travel and subsequent spread of #COVID19 @MITEcon nature.com/articles/s4159…
Lack of rigor in approving #aducamumab for Alzheimer's disease may lead to serious harm.
Worldview from Joel Perlmutter @WUSTLmed who resigned from the FDA Expert Advisory Committee. A separate Worldview by Jeffrey Cummings presents an alternative opinion.
nature.com/articles/s4159…
Approval of #aducanumab will herald a new era in Alzheimer’s disease care and research.
Worldview from Jeffrey Cummings @unlv. An alternative opinion is presented by Joel Perlmutter in a separate Worldview.
nature.com/articles/s4159…
A record number of gene therapy trials are underway, and despite some recent failures, researchers remain optimistic.
News Feature from Carrie Arnold @edbites
nature.com/articles/s4159…
⭐Research Highlight: A treatment that prevents #COVID19 in household contacts of infected people could help protect those who are high-risk or vulnerable, according to new trial data published in @NEJM
nature.com/articles/d4159…
A randomised crossover #clinicaltrial testing rapid-acting insulin aspart delivered in a closed-loop system vs. standard care demonstrates increased time in range in patients with type 2 #diabetes who require dialysis. #NMEDClinical @ckboughton @MRL_Cam nature.com/articles/s4159…
In the phase 2 PASSPORT study treatment with the anti-tau antibody gosuranemab did not show clinical benefit in participants with supranuclear #palsy suggesting that N-terminal tau neutralization does not translate to clinical efficacy #NMEDClinical nature.com/articles/s4159…
In our latest News and Views: Karen Duff and @Ed_Jabbari review the latest clinical data on tau-targeting antibodies in progressive supranuclear palsy
@ucl #neurodegeneration
nature.com/articles/s4159…
Southeast Asia is an emerging hotspot for COVID-19.
Correspondence from @TChookajorn and colleagues, @MahidolU Thailand.
nature.com/articles/s4159…
In a first-in-human #phase1trial, autologous tumor infiltrating lymphocyte therapy in patients with metastatic #lungcancer is safe and shows clinical efficacy in association with neoantigen-specific T cell activity @BenCreelan @MoffittNews #NMEDClinical nature.com/articles/s4159…
In our latest News and Views: Stanley Riddell and colleagues @fredhutch discuss promising new data from a #clinicaltrial which used patients own T cells for #NSCLC therapy.
#immunotherapy # TILtherapy
nature.com/articles/s4159…
⚡Our August issue is live⚡ Our latest content includes #clinicaltrial data on #type2diabetes, #heart failure, #palsy, #lungcancer and #leukemia, studies on the #microbiome and bacteriophage therapy, updates on #COVID19 vaccines and much more... nature.com/nm/volumes/27/…
⚡Read our new editorial⚡
"Gene therapies should be for all" #genetherapy #equity nature.com/articles/s4159…
In our latest News and Views: John Cleland and colleagues discuss the latest clinical data on targeting fibrosis for treatment of #heartfailure
@UofGlasgow @CIBER_CV
nature.com/articles/s4159…
A record number of gene therapy trials are underway, and despite some recent failures, researchers remain optimistic.
News Feature from Carrie Arnold @edbites
nature.com/articles/s4159…
In our latest Perspective, @DrRoyHerbstYale and colleagues discuss the future of #precisionmedicine in #NSCLC
nature.com/articles/s4159…
In a double-blind, randomized phase 2 #clinicaltrial, treatment of patients with #heartfailure with preserved ejection fraction (HFpEF) with the oral anti-fibrotic agent pirfenidone reduced myocardial fibrosis. #NMEDClinical @NWhearts @OfficialUoM nature.com/articles/s4159…
AI algorithms used for diagnosis and prognosis must be explainable and must not rely on a black box.
Worldview from @ShinjiniKundu, @HopkinsMedicine
nature.com/articles/s4159…
Research Highlight: A study published in @Nature sheds light on the complex processes that control the timing of menopause, with implications for fertility and health.
nature.com/articles/d4159…
Interim analysis from the randomized #phase3 JUPITER-02 #trial shows addition of anti–PD-1 toripalimab to standard gemcitabine/cisplatin improves progression-free survival in patients with recurrent or metastatic #nasopharyngeal #carcinoma #NMEDClinical nature.com/articles/s4159…
Remove obstacles to sharing health data with researchers outside of the European Union.
Comment from @RosaCastroB @HeidiBBentzen and colleagues @FedEuroAcadMed
nature.com/articles/s4159…
Whole genome #sequencing of metastatic #biopsies longitudinally sampled during the course of anti-cancer treatment reveals the actionable #cancer genome remains relatively stable over time. @NKI_nl @oncodeinstitute @jorisvandehaar #genomics nature.com/articles/s4159…
Booster vaccination with an mRNA #vaccine, irrespective of the vaccine used for the first dose, elicited higher levels of spike-specific antibodies & T cells than booster vaccination with the ChAdOx1-nCov-19 #COVID19 @MartinaSester @Saar_Uni @Stk_Saarland
go.nature.com/3kYO6aO
Programs for treating malnutrition in children should consider how food formulations affect postnatal gut microbiome development.
Comment from @therealRYC, Jeffrey Gordon and colleagues, @WUSTLmed
nature.com/articles/s4159…
The recent failure of a gene therapy for Huntington’s disease was devastating for patients, but researchers remain optimistic.
News Feature from Carrie Arnold @edbites
nature.com/articles/s4159…
In a phase 1 trial, bispecific CAR T cells targeting CD19 and CD22 exhibit clinical activity and low toxicity in patients with large B-cell #lymphoma and B-cell acute lymphoblastic #leukemia #NMEDClinical @jayspiegel25 @LoriMuffly @StanfordBMT_CT
nature.com/articles/s4159…
AI algorithms used for diagnosis and prognosis must be explainable and must not rely on a black box.
Worldview from @ShinjiniKundu, @HopkinsMedicine
nature.com/articles/s4159…
A randomised crossover #clinicaltrial testing rapid-acting insulin aspart delivered in a closed-loop system vs. standard care demonstrates increased time in range in patients with type 2 #diabetes who require dialysis. #NMEDClinical @ckboughton @MRL_Cam nature.com/articles/s4159…
⭐ New Research Highlight: A review published in @JAMAPediatrics sheds light on the experiences of #transgender and #nonbinary young people in healthcare.
nature.com/articles/d4159…
New conference alert!⚠️
If you are interested in know the latest on gene therapy, cell therapy and tissue engineering you won't want to miss #NatconfTissue21 this November! Organized by @SanRaffaeleMI @NatureComms.
conferences.nature.com/TissueTherapies
Retweeted by Nature Medicine In a phase 4 trial, CoronaVac, an inactivated #SARSCoV2 vaccine, elicited significantly reduced IgG and neutralizing antibodies in patients with autoimmune rheumatic diseases versus age- and sex-matched healthy controls #NMEDClinical #rheumatology #COVID19 nature.com/articles/s4159…
How to implement translational medicine in the clinic - a pilot from Academia Europaea @acad_euro, @pte1367 and @semmelweishu.
Correspondence from Péter Hegyi and colleagues.
nature.com/articles/s4159…
Remove obstacles to sharing health data with researchers outside of the European Union.
Comment from @RosaCastroB @HeidiBBentzen and colleagues @FedEuroAcadMed
nature.com/articles/s4159…
Interim analysis from the randomized #phase3 JUPITER-02 #trial shows addition of anti–PD-1 toripalimab to standard gemcitabine/cisplatin improves progression-free survival in patients with recurrent or metastatic #nasopharyngeal #carcinoma #NMEDClinical nature.com/articles/s4159…
Programs for treating malnutrition in children should consider how food formulations affect postnatal gut microbiome development.
Comment from @therealRYC, Jeffrey Gordon and colleagues, @WUSTLmed
nature.com/articles/s4159…
#Phage immunoprecipitation sequencing illustrates the wide breadth of systemic microbiota-specific #antibody responses, which are more longitudinally stable than #gut #microbiome species abundances in a cohort of healthy individuals @segal_eran @segal_lab
ow.ly/A6lI50Fz0JH
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