JAMA

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In this randomized clinical trial that included 412 adults, 90-day mortality was 41.5% in the extracorporeal carbon dioxide removal group and 39.5% in the standard care group, a difference that was not statistically significant ja.ma/3hSspHd #ISICEM21
In this randomized clinical trial that included 412 adults, 90-day mortality was 41.5% in the extracorporeal carbon dioxide removal group and 39.5% in the standard care group, a difference that was not statistically significant ja.ma/2XDWDa3 #ISICEM21
In this randomized clinical trial that included 412 adults, 90-day mortality was 41.5% in the extracorporeal carbon dioxide removal group and 39.5% in the standard care group, a difference that was not statistically significant ja.ma/3hRu7IG #ISICEM21
Multicenter RCT found, among critically ill patients, targeting oxygenation to a low-normal range compared with a high-normal range did not result in a statistically significant reduction in organ dysfunction ja.ma/3nvUurj
Multicenter RCT found, among critically ill patients, targeting oxygenation to a low-normal range compared with a high-normal range did not result in a statistically significant reduction in organ dysfunction ja.ma/3z4QYX2
Multicenter RCT found, among critically ill patients, targeting oxygenation to a low-normal range compared with a high-normal range did not result in a statistically significant reduction in organ dysfunction ja.ma/3lpzTCs
Randomized clinical trial findings do not support the use of inosine as a treatment for early #Parkinsondisease ja.ma/3tJ64R8
Among patients with advanced or metastatic esophageal squamous cell carcinoma, the addition of camrelizumab to chemotherapy, compared with placebo and chemotherapy, significantly improved overall survival and progression-free survival ja.ma/3hwMEKf
Among patients with advanced or metastatic esophageal squamous cell carcinoma, the addition of camrelizumab to chemotherapy, compared with placebo and chemotherapy, significantly improved overall survival and progression-free survival ja.ma/2VLstAI
Among patients with advanced or metastatic esophageal squamous cell carcinoma, the addition of camrelizumab to chemotherapy, compared with placebo and chemotherapy, significantly improved overall survival and progression-free survival ja.ma/3kaLypf
Randomized clinical trial found that among children with active #asthma, use of a school-wide integrated pest management (IPM) program or HEPA filter purifiers in the classrooms did not significantly reduce symptom-days with asthma ja.ma/38NO8uU
Among critically ill patients requiring fluid challenges, infusing at a slower rate compared with a faster rate did not reduce 90-day mortality ja.ma/3h77UWU
Among critically ill patients requiring fluid challenges, treatment with a balanced solution compared with saline solution did not significantly reduce 90-day mortality ja.ma/2WVwEdh
Analysis found no significant associations between vaccination with mRNA #COVID19 vaccines and selected serious health outcomes 1-21 days after vaccination, although confidence intervals were wide for some rate ratio estimates and additional follow up ja.ma/3n01xrX
Based on a sample of blood donations in the United States from July 2020 through May 2021, estimated #SARSCoV2 seroprevalence increased over time and varied by age, race, ethnicity, and geographic region ja.ma/3kGWj1C
In this randomized clinical trial that included 412 adults, 90-day mortality was 41.5% in the extracorporeal carbon dioxide removal group and 39.5% in the standard care group, a difference that was not statistically significant ja.ma/3DrNtxr #ISICEM21
Multicenter RCT found, among critically ill patients, targeting oxygenation to a low-normal range compared with a high-normal range did not result in a statistically significant reduction in organ dysfunction ja.ma/3ysPXrt #ISICEM21
Among pregnant women, receipt of the BNT162b2 vaccine was associated with a lower risk of incident #SARSCoV2 infection ja.ma/3jcDGD0
In 6 areas of the US from 2001 to 2017, the estimated prevalence of diabetes among children and adolescents increased significantly for both type 1 and type 2 #diabetes ja.ma/3zfI6yO
Based on NHANES data from US adults, the estimated prevalence of #diabetes increased significantly between 1999-2000 and 2017-2018, and only an estimated 21% of adults with diagnosed diabetes achieved all 3 risk factor control goals in 2015-2018 ja.ma/3sKmkRh
Among individuals w a singleton first live birth in the US from 2011 to 2019, rates of gestational diabetes increased across all racial & ethnic subgroups. Differences in absolute gestational diabetes rates were observed across race and ethnicity subgroups ja.ma/3xOZn0h
Study found that in the US from 2002 through 2016, there were differences in age-standardized health care spending by race and ethnicity across different types of care ja.ma/3jZ11Yh
In a serial cross-sectional survey study of US adults from 1999 to 2018, racial and ethnic differences in self-reported health status, access, and affordability improved in some subgroups, but largely persisted ja.ma/37UUzM0
In this exploratory study of Medicare beneficiaries in 2015-2018, enrollment in Medicare Advantage vs traditional Medicare was significantly associated with better outcomes for access and quality among minority beneficiaries ja.ma/2W1yEk8
A prospective meta-analysis from WHO estimates the association between administration of IL-6 antagonists vs usual care or placebo and 28-day all-cause mortality and other outcomes in patients hospitalized for #COVID19 ja.ma/3Cz6RYO
JAMA Clinical Guidelines Synopsis: @AmerUrological’s 2020 guideline on management of patients with microhematuria ja.ma/3fQMXie
Systematic review to support the 2021 USPSTF Recommendation Statement on screening for gestational diabetes summarizes published evidence on the benefits and harms of screening for and treatment of diabetes in asymptomatic pregnant persons ja.ma/3AzvtPn
USPSTF Recommendation: Screening for Gestational Diabetes includes a B recommendation for screening at 24 weeks' gestation or later, but evidence is insufficient to assess the balance of benefits and harms in asymptomatic pregnant persons before 24 weeks ja.ma/3xvpcCk
Among outpatients with #SARSCoV2 infection, treatment with a single dose of oral #azithromycin compared with placebo did not result in a greater likelihood of being free of symptoms at day 14 ja.ma/3Asi8Iw #COVID19
Among outpatients with #SARSCoV2 infection, treatment with a single dose of oral #azithromycin compared with placebo did not result in a greater likelihood of being free of symptoms at day 14 ja.ma/3lP2xP7 #COVID19
Among outpatients with #SARSCoV2 infection, treatment with a single dose of oral #azithromycin compared with placebo did not result in a greater likelihood of being free of symptoms at day 14 ja.ma/2Xf703r #COVID19
From 1999 to 2018, the estimated proportion of energy intake from consumption of ultraprocessed foods increased in the US among youths and comprised the majority of their total energy intake ja.ma/2U7ahAF
Among critically ill patients requiring fluid challenges, infusing at a slower rate compared with a faster rate did not reduce 90-day mortality ja.ma/37MqVsF
Among critically ill patients requiring fluid challenges, infusing at a slower rate compared with a faster rate did not reduce 90-day mortality ja.ma/3AtXnfx
Among critically ill patients requiring fluid challenges, infusing at a slower rate compared with a faster rate did not reduce 90-day mortality ja.ma/3AtSMtD
#Azithromycin and IL-6 Antagonists for #COVID19, Ultraprocessed Food Consumption Among Youth, Screening for #GestationalDiabetes, and more. The August 10, 2021, issue of JAMA is now available ja.ma/3xBiPNG
Among critically ill patients requiring fluid challenges, treatment with a balanced solution compared with saline solution did not significantly reduce 90-day mortality ja.ma/3jHlKQf
Among critically ill patients requiring fluid challenges, treatment with a balanced solution compared with saline solution did not significantly reduce 90-day mortality ja.ma/3s6tGxY
Among critically ill patients requiring fluid challenges, treatment with a balanced solution compared with saline solution did not significantly reduce 90-day mortality ja.ma/3fRXedR
As medical devices have become more complex over the past 45 years, their oversight by @US_FDA has evolved as well, integrating regulatory changes such as expedited pathways and user fee funding ja.ma/3fubSb5
Retrospective cohort study found #opioid dose tapering was associated with increased risk for overdose and mental health crisis, but interpretation of these findings is limited by the study design ja.ma/2TVAHFs
In this randomized clinical trial, active management was more effective than expectant management in achieving resolution of a persistent pregnancy of unknown location without a change in initiated management strategy ja.ma/2VlYgIb
Active vs Expectant Management of Nonviable Pregnancy of Unknown Location, Opioid Dose Tapering and Overdose, FDA Regulation of Medical Devices, and more. The August 3 issue of JAMA is now available ja.ma/2Vbclbv
In this stepped-wedge, cluster RCT, among infants and children anticipated to require prolonged mechanical ventilation, a sedation & ventilator liberation protocol intervention resulted in a reduction in time to first successful extubation ja.ma/3A7YfGm
In this stepped-wedge, cluster RCT, among infants and children anticipated to require prolonged mechanical ventilation, a sedation & ventilator liberation protocol intervention resulted in a reduction in time to first successful extubation ja.ma/3rOLptT
In this stepped-wedge, cluster RCT, among infants and children anticipated to require prolonged mechanical ventilation, a sedation & ventilator liberation protocol intervention resulted in a reduction in time to first successful extubation ja.ma/3fqI9zZ
JAMA Clinical Guidelines Synopsis summarizes the @AASLDtweets/@IDSAInfo 2019 guideline update on screening for #hepatitisC virus ja.ma/3f3K8db
Study findings may inform investigations of the possible association between the ChAdOx1 nCoV-19 (AstraZeneca/Oxford) and Ad26.COV2.S (Janssen/Johnson & Johnson) #COVID19 vaccines and cerebral venous sinus thrombosis with thrombocytopenia ja.ma/3iO5lJc
Study findings support the use of a 7-day course of ciprofloxacin or trimethoprim/sulfamethoxazole as an alternative to a 14-day course of antibiotics for treatment of afebrile men with suspected UTI ja.ma/3y9QOy2
#HeartFailure Quality Improvement RCT, 7 vs 14 Days of #Antibiotics for Male UTI, Does This Patient Have #Hypertension?, and more. The July 27, 2021, issue of JAMA is out now ja.ma/2Wr1SZD
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