Eric Topol
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BA.5 has the most transmissibility and immune escape of any version of the virus since the pandemic began. Although its spike(S) sequence is nearly the same as BA.4, there are several mutations in other parts of the virus that may account for its⬆️fitness outbreak.info twitter.com/EricTopol/stat…
This is the simple graph that should have been in the paper, #dataviz from @TheEconomist for saving ~20 million lives in the first year of Covid vaccinations
economist.com/graphic-detail… @ECONdailycharts
US Covid hospitalizations are continuing to increase as the BA.4/5 variants become dominant, fortunately at a far lesser slope than BA.1
Genetic, antigenic distances, & fitness of Omicron subvariants. While BA.4/5 are becoming dominant around the world, we are several months behind the virus's evolution
Unfathomable there isn't a full court press for a pan-β-coronavirus vaccine
(The🦠is more fit than the humans)twitter.com/EricTopol/stat…l7
Hospital admissions for Covid in countries with rising BA.4/5
@OurWorldInData
This consistent finding reflects the immune escape property of BA.4/5. We don't yet know the clinical impact of the Omicron booster, directed vs BA.1, which is genetically and antigenically distant/distinct from BA.4/5
Important to note that both Moderna and Pfizer/BioNTech Omicron (BA-1) booster shots had 3-fold lower neutralizing antibody response to BA.4/5 than to BA.1
[Pfizer data just put out this morning)
The BA.5 variant is a beast w/r to immune escape and transmissibility
—UK report today on its growth advantage relative to BA.2.12.1 and BA.4
assets.publishing.service.gov.uk/government/upl…
—San Diego wastewater today
searchcovid.info/dashboards/was…
A real CDC would be aggressively disseminating these data and doing everything possible to prevent unnecessary deaths from Covid twitter.com/EricTopol/stat…
"The editors of the New England Journal of Medicine strongly condemn the U.S. Supreme Court’s decision."
nejm.org/doi/full/10.10…
Today, the CDC Director flippantly dismissed the importance of counting rapid tests.
"You don't need to count the rain drops to know how hard it's raining."
Wrong. Governments are making bad policy decisions to drop public health protections based on inaccurate testing numbers.
Retweeted by Eric Topol Not just England. The BA.4/5 wave in Europe
ft.com/content/825af0… and @OurWorldInData
New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1, BA.2
2 boosters: 99% reduction
1 booster: 86% reduction
Vaxx, no boosters: 81% reduction
covid.cdc.gov/covid-data-tra…
Retweeted by Eric Topol "Trust in science has actually become a matter of life and death.”—@NaomiOreskes
thelancet.com/journals/lance… @TheLancet Cover and profile of Professor Oreskes
🆕@TheLancetInfDiss
In the 1st year of Covid vaccinations, ~20 million deaths were prevented worldwide (data from 185 countries)
Another ~600,000 lives would have been saved if the@WHOO 40% target been achievedthelancet.com/journals/lanin…N@azraghanii@imperialcollegee@MRC_OutbreakkK
A new study of the "atomic-level dynamics by multiple microseconds simulations" for how the #SARSCoV2 spike gets modified to more efficiently enter host cells
pnas.org/doi/full/10.10…
@PNASNews
Just out @ScienceMagazine
"Our findings highlight the urgent need to find next-generation COVID-19 vaccines and broad-spectrum therapeutics, as well as to tighten non-pharmaceutical measures to reduce acute and chronic disease burden (#LongCovid)..."
science.org/doi/10.1126/sc…
The antigen distance map of #SARSCoV2 variants through BA.1 and BA.2
"BA.1 and BA.2 both escape vaccine-induced antibody responses as a result of different antigenic characteristics"
Needs a BA.4/5 update, off the chart science.org/doi/10.1126/sc… @SciImmunology
A bacteria, as a microbe, is expected to only be visible via a powerful compound microscope. Until this one that was discovered to be macroscopic, reported today @ScienceMagazine science.org/doi/10.1126/sc…
@PetraLevin
Easy to remember its name if you like very large margaritas😉4
The Israeli researchers nailed this down back in February and have published extensively on the protection of the 4th shot for reducing death and severe disease
twitter.com/erictopol/stat…
Only 1 in 4 Americans age 50+ have had a 2nd booster.
covid.cdc.gov/covid-data-tra…
Please go for it. It could be lifesaving.
New @CDCgov data on 2nd booster protection from death for people age 50+, compared with unvaccinated, through Omicron BA.1, BA.2
2 boosters: 99% reduction
1 booster: 86% reduction
Vaxx, no boosters: 81% reduction
covid.cdc.gov/covid-data-tra…
More @TheEconomist today on @mcuban's @costplusdrugs and @CivicaRx efforts to take down drug costs
economist.com/business/2022/…
On the amazing 300 million smell receptors in dogs that can sniff out Covid and diseases
nature.com/articles/d4158…
@Nature @PVWDCvet @juliannaphos
A few added mutations in the spike sequence (BA.4/5) are leading to even more immune evasiveness and a new Covid wave in many places around the world
"Astoundingly, they found that more than 78% of all the CTCs obtained were from the samples taken during the resting [sleep] phase."
nature.com/articles/d4158…
@NatureNV
The exact opposite:
@VirusesImmunity tips for 1st rate science communication on @Twitter
nature.com/articles/s4159…
@NatImmunol
Accompanying editorial
nejm.org/doi/full/10.10…
by @skr9skr9 and Denise Jamieson
Largest study of #LongCovid in kids, a nationwide Denmark report with age-sex-matched controls @LancetChildAdol
Higher odds of > 2 months symptom(s) by age:
0-3 years 1.8X
4-11 years 1.2X
12-14 years 1.2X
thelancet.com/journals/lanch…
Details of symptoms by age group vs controls below
How vaccinating 1 person protects 2
Expectant mothers and their newborns
nejm.org/doi/full/10.10…
New @NEJM
No wonder why Omicron subvariants BA.2.12.1 and BA.4/5 are causing a lot of infections and reinfections in people who've have been vaccinated or had BA.1 or BA.2 infections, respectively. Increasing immune escape.
nejm.org/doi/full/10.10…
Important paper for our understanding of virus transmission by speech. There may be a lot more volume in coarse aerosols than reported in recent studies, due to methodological artifacts. twitter.com/EricTopol/stat…
Retweeted by Eric Topol The dissemination via @Twitter of misleading information that "endangers people's lives and public health interventions" during the pandemic, and suspension of 1 of 5 people using certain hashtags
journals.plos.org/plosone/articl… @PLOSONE @IDInformaticsMD
@culehmann @docfordata
"We find that, in both patients with breast #cancer and mouse models, generation of CTCs [circulating tumor cells] is highly restricted to the rest phase"
Should anti-cancer therapy be timed to a person's circadian rhythm?
nature.com/articles/s4158… @Nature
Discussion about the impact of Omicron subvariants with @biannagolodryga @CNN @amanpour
cnn.com/videos/tv/2022…
Some @LongCovid is tied to dysautonomia, which brings up the potential of stimulation of the vagus nerve. A small, novel, randomized pilot study addressed this hypothesis
researchsquare.com/article/rs-171…
The association of the rise on hospital admissions and Omicron subvariants in the UK
Genomic data covariants.org thru June 11
Hospital data via @chrischirp @IndependentSage
A new report of a sensor bracelet that detected Covid 2 days in advance of symptom onset
bmjopen.bmj.com/content/12/6/e…
@BMJ_Open
Some good news about the Omicron BA.1-specific (bivalent w/ ancestral) booster vaccine @moderna_tx today: induced a 5.4-fold increase in neutralizing antibodies vs BA.4/5 (albeit 3-fold lower than vs. BA.1)
Why is this important?
erictopol.substack.com/p/a-reinfectio…
"no excuse for why [pan-beta-coronavirus & nasal] vaccines are not being aggressively pursued given relentless increased SARS-CoV-2 immune-evasiveness"
via @EricTopol erictopol.substack.com/p/a-reinfectio…
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