Decades ago in biochem talks, profs could fall asleep, wake up at the end & ask what concentration of Mg did you use & sound intelligent. Today, ppl are doing the same by vague invocation of an epigenetic mechanism. If you don’t specify what you want to test, you’ve said nothing
Monarch butterfly caterpillars hatching in Santa Monica!
We planted some California indigenous milkweed a few weeks ago.
They will eat the milkweed and get ready to go into chrysalis.
PS. If you are one of those parents, know that my thoughts are with you. Ppl like myself & @ranjitbindra are working on specific cancer approaches for specific tumors. Pls don’t be suckered by bad science, false claims & book promotion. False promises hurt ppl every day
also, please stop putting NR in a basket with debunked snake oils like resveratrol or pterostilbene. eating veggies & blueberries is great for 1000s of reasons but it doesn't help legitimate NAD research to be associated with junk science /end
we advise NR trialists to select the target population carefully & do the study for sufficient time to see results while combining with approaches like exercise that are complementary doi.org/10.1093/ajcn/n… /8
the NAD system comes under pressure from many types of common stresses including sun (DNA damage), oxygen (ROS damage), alcoholic liver damage & coronavirus infection. this is precisely the reason why there are so many clinical trials of NR for conditions of metabolic stress /6
i do believe that ppl can age better & it usually starts with increased physical/mental activity, matching food consumption to energy expenditure & avoiding the killers of smoke, gun violence, drugs, SARS-CoV-2, etc /5
while many of these conditions are age-associated, aging is not 1 thing & clearly their kid's cancer is a distinct entity that has little resemblance to the biohacking experiments of grown men & women /4
i remind ppl that NR is active in many rodent models of human diseases & conditions of metabolic stress in which the NAD system is under attack (heart failure, fatty liver, neurodegeneration, central brain injury, etc) /3
experiences like these make me shudder at the 💩 being peddled in the name of "anti-aging." no phd scientist should tell any such parent that their kid's rare malignancy is curable with their favorite elixir /2
Dr. David B. Allison, Dean of @IUSPH, is the 2020 recipient of the #ASN Nutritional Sciences Award! Professor Allison is known as a staunch advocate for rigor in research methods and unvarnished truthful communication of research results. Congratulations!
Every Memorial Day, this picture gets me. While some of us are at the beach eating BBQ and burgers...some spend it like this. Her fiancé was killed by a roadside bomb in Iraq. Gut check kinda stuff. Monday, please honor our fallen men and women. They’ve earned it...
So many things interesting about this image. Throughout history, our physical activity was linked to food acquisition (eg hunting & gathering). With a penal treadmill, forced activity was linked to food production. Today, activity & food are disconnected for most ppl twitter.com/billionswriter…
4. Different conditions of metabolic stress are different. They don’t converge on SIRT functions. Blood NAD is a biomarker of B3 dose generally but not a direct measure of efficacy. Reject soundbites. Follow the science. Thanks for the question
3. Yes we recently unblinded study with postpartum rats with 9 different types of food that indicates that trp, NA, NAM, NR & NMN are not equivalent for pup survival & development into adulthood. Still analyzing massive amounts of data but we will release when we can
2. Main diffs between activity of these B3s is genes to convert to NAD, NADPH etc. NA pathway not expressed in several key tissues like neuron. NR pathway typically upregulated when NAD under attack, eg heart failure, nerve damage & coronavirus infection
Many thoughts: 1. Know that blood is rarely the target tissue we are trying to address. These mito disease pts have a muscle disorder but are walking around with low blood NAD. Blood NAD easy to measure and can be increased by NR, NA or NAM twitter.com/sentineliberta…
that we will work extra hard to promote stimulating scientific interactions between & within research groups. we know that biochem & mol biol are more important now than ever & have a terrific 1st year grad class arriving. we will get through this together.
Early in year, I declined a trip to HK because of known cases of C19. Little did I know that US would become the place that, despite having been provided much warning, did not control its spread. Hats off and masks on to HK twitter.com/latimes/status…
“Viewing [cancer] as a single disease that will yield to a single approach is no more logical than viewing neuropsychiatric disease as a single entity that will response to one strategy.” A “magic bullet” is unlikely.
— The Emperor of All Maladies, Dr. Sid Mukherjee
Just published @CellCellPress: From 60 patients convalesced from #COVID19, single-cell sequencing of their B cells-> 14 potent neutralizing monoclonal antibodies. With 1 #3D crystal structure, and model efficacy in hACE2 mice as preventive therapy. Wow.👍cell.com/cell/fulltext/…aK
Twiends uses the Twitter™ API, displays it's logo & trademarks, and is not endorsed or certified by them. These items remain the property of Twitter.
We do not sell followers, we only provide display advertising. Bots & fake accounts are not permitted on twiends.
Report This User?
Is this user posting inappropriate content?
Reporting them will flag them to our moderators for review.